Antibody Topoisomerase II alpha (Topo IIa)
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Antibody Topoisomerase II alpha (Topo IIa) plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topo IIa is the predominant mechanism of resistance to several chemotherapeutic agents.
| INTENDED USE | IVD |
|---|---|
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | 31 |
| ISOTYPE | Mouse IgG1 |
| ANTIGEN | Topoisomerase II alpha |
| LOCALIZATION | Nuclear |
| POSITIVE CONTROL | Cervix or tonsil |
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